A group of local animal control workers' lives are complicated by the fact that animals are simple, but humans are not. Leading the crew is Frank, an opinionated, eccentric animal control officer who may not have gone to college but is still the most well-read person in the room. In his past life as a cop, Frank tried to expose corruption in his department, but his efforts got him fired, leaving him cynical and curmudgeonly. Despite his rough exterior, he is blessed with an almost superhuman ability to understand animals.
Nanotechnology researcher Wang Miao is taken to the Joint Operations Center by police officer Shi Qiang, who's investigating the mysterious suicide wave among scientists worldwide, and recruited to sneak into an organization called the Frontiers of Science to help the investigation. When Wang Miao is contacted by the leader of the organization, Shen Yufei, she introduces him to a sophisticated VR video game called Three-Body, but soon he discovers that it's more than just a game.