Three women – 27 year old Tokyo office worker Mire Yoshizuki, 22 year old fourth-year college student Sora Nagase, and 20 year old boyish, part-time Hiroshima okonomiyaki shop worker and freelancer Reika Kawatani – are drawn together by a magic gem.
Yumeji has the ability to see the dreams of other people around him. When Yumeji meets Nightmare Merry, a dream demon seeking to return to her own world he uses his power to assist her.
Professor Utonium and his son Ken are studying the strange Chemical X. When a mochi cake falls into the formula, it changes into Chemical Z. Ken fires a ray of Chemical Z at a glacier in Tokyo Bay, however that causes strange lights to scatter, some of them aim at three normal girls, Momoko, Miyako, and Kaoru. This gives them the power to transform into superheroes, the Powerpuff Girls Z!