Skipper, Kowalski, Rico and Private join forces with undercover organization The North Wind to stop the villainous Dr. Octavius Brine from destroying the world as we know it.
Animal pals Alex, Marty, Melman, and Gloria are still trying to make it back to New York's Central Park Zoo. They are forced to take a detour to Europe to find the penguins and chimps who broke the bank at a Monte Carlo casino. When French animal-control officer Capitaine Chantel DuBois picks up their scent, Alex and company are forced to hide out in a traveling circus.
Po and his friends fight to stop a peacock villain from conquering China with a deadly new weapon, but first the Dragon Warrior must come to terms with his past.
After Megamind, a highly intelligent alien supervillain, defeats his long-time nemesis Metro Man, Megamind creates a new hero to fight, but must act to save the city when his "creation" becomes an even worse villain than he was.
When Susan Murphy is unwittingly clobbered by a meteor full of outer space gunk on her wedding day, she mysteriously grows to 49-feet-11-inches. The military jumps into action and captures Susan, secreting her away to a covert government compound. She is renamed Ginormica and placed in confinement with a ragtag group of Monsters...
Alex, Marty, and other zoo animals find a way to escape from Madagascar when the penguins reassemble a wrecked airplane. The precariously repaired craft stays airborne just long enough to make it to the African continent. There the New Yorkers encounter members of their own species for the first time. Africa proves to be a wild place, but Alex and company wonder if it is better than their Central Park home.
When the Valley of Peace is threatened, lazy Po the panda discovers his destiny as the "chosen one" and trains to become a kung fu hero, but transforming the unsleek slacker into a brave warrior won't be easy. It's up to Master Shifu and the Furious Five -- Tigress, Crane, Mantis, Viper and Monkey -- to give it a try.