Andrea (Riccardo Maria Manera) is a young man who lives with the surprises and hardships of life. He lives with his best friend, seeks to complete his studies and has an ex-girlfriend who plays with him like cat and mouse. When he discovers that he has an incurable disease, the world collapses on him. Can an illness change a person's life... for the better? Thanks to Giulia (Jenny De Nucci), Andrea will understand that the time has come to assume what remains of her own existence.
Irma (Claudia Gerini), Eugenia (Angela Finocchiaro), Miranda (Caterina Guzzanti) and Rina (Paola Minaccioni) are four different women, each with their own character, their own weaknesses and their own eccentricities, but linked by a deep and lasting knowledge over time, united and marked by their essential card games. When they decide to participate in a national buraco tournament and get out of their everyday life, they will suddenly find themselves with their cards exposed. Life always offers a second chance and love can go back to upsetting at any age. After all, it is the game of burraco that has taught him that a game must be played completely, to the end, and that no result is ever taken for granted.
The life of Giorgio, a mediocre journalist, changes abruptly when the director of the newspaper decides to transfer him to a provincial office. Only the kidnapping of young Carlo gives him back his work as a correspondent.