Cha Yo-Han—an arrogant but genius doctor of anesthesiology—and Kang Shi-Young—a smart, warm resident of anesthesiology—work together to help people with mysterious cases of acute or chronic pain.
Tae Ho and Sang Goo are two men who constantly fought at work and hates each other even more now that they’re both the heads of rival companies. When their children Do Hee and Young Joon get married, the bickering fathers are forced to become in-laws.