The story takes place in a fantasy world consisting of humans, Dragonoids and Monsters. There is a relative harmony between the three races. There are also Drops, spherical objects that come out of the planet, which can power up the Monsters. Humans and Dragonoids can take on the role of Dragon Callers if they have the capability to see the Drops, wherein, they form bonds with monsters. Currently, the planet is facing Drop Impacts, occurrences where a large amount of Drops are suddenly generated in a single area (and can also spread), which affects the lands and makes the Monsters berserk. In fact, one of the main duties of Dragon Callers is to settle the Drop Impacts by stabilizing the Drop distribution.
The Universal Century, a history marked by space colonization and space warfare, has passed. Humanity's prosperity, which ushered in a new era known as the Regild Century (R.C.), was believed to endure alongside global peace. In RC 1014, Bellri Zenam, a pilot in training of the Capitol Guard is somehow chosen by the G-Self - a highly maneuverable Mobile Suit of unknown origin - to lead to uncover hidden truths that will shake the peace of the Regild Century era.
Set in the Shinigami technical school for weapon meisters, the series revolves around 3 groups of each a weapon meister and a human weapon. Trying to make the latter a "Death Scythe" which is the highest title for a weapon and thus fit for use by the Shinigami, they must collect the souls of 99 evil humans and 1 witch. Maka & Soul Eater, Black Star & Tsubaki, and Death the Kid with Patty and Liz Thompson are the characters Soul Eater revolves around. Besides taking the time to gather souls, these students of Shibusen defend Death City from some of the most powerful of creatures while still attending school and trying to become stronger.