Tonino Esposito is the son of the fearsome Camorra boss of Rione Sanità, Naples. Unlike him, however, Tonino is clumsy and utterly innocuous—a decent person at heart—and so when his father dies he's passed over in matters of succession. His pride wounded, he doesn't resign himself and tries to be his own boss, only managing to make a fool of himself. When he finds out that his daughter is dating to the son of the judge prosecuting the new boss, Tonino sees the opportunity to prove himself in front of his family and all of Naples.
When his girlfriend Giorgia leaves him for his boss, journalist Giulio suddenly finds himself without a woman and with no job. Determined to win back his ex, he attends Valeria's classes, who teaches single men the art of seduction, convinced that relationships between people are motivated by simple biological stimuli.
Arturo Meraviglia is a struggling impresario who has to take care of Gioele and Rebecca, two children "inherited" by an old uncle. When he realizes that little Gioele has superpowers, his luck changes.
A married couple must get their hands dirty when a bunch of mobsters start using their new home as a deposit for illegal material.
Gaetano and Gennaro Tavani are two brothers on the threshold of fifty, they are nine months apart from each other. The first, Gaetano, has little acting experience behind him, while the second, Gennaro, has written some screenplays in the past and directed some small films as a director. Together they opened a "cinematic" production company, Tavani Brass, mainly dealing with small commercials, pre-eighteenth birthday videos and weddings. Their dream is to be able to make a successful film. Given Checco Zalone's exploits, the two propose to an unknown Neapolitan singer, Chicco Resina, to create a product capable of intercepting the success of the blockbuster film in Italy.
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